Sesso HD et al., Am J Clin Nutr 2022 (COSMOS, multivitamins, cancer and cardiovascular disease)

PMID 35294969

Randomized, placebo-controlled 2x2 factorial trial: 21,442 US adults (women aged 65 and older, men aged 60 and older), daily multivitamin versus placebo, median 3.6 years. Invasive cancer HR 0.97 (95% CI 0.86–1.09); cardiovascular events HR 0.98 (95% CI 0.86–1.12).