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VERVE-102 and CTX310 edit liver genes to lower LDL cholesterol after a single infusion. The 2026 papers report large drops in a few dozen selected patients — open-label, no placebo, and not one cardiovascular event counted.
Four investigational drugs lower lipoprotein(a) sharply in phase 2 trials. In September 2026 the first trial that counted heart attacks and strokes missed its endpoint. What was measured, on whom, and what the result does not settle.
Retatrutide, a once-weekly drug acting on three hormone receptors, now has published phase 3 trials in obesity and type 2 diabetes. Here is how much weight participants lost, in whom, with which side effects, and what the trials have not yet measured.
Anti-VEGF injections have preserved vision in large randomised trials of regular treatment. Newer drugs and an implant were shown to be no worse at longer intervals, each with its own safety profile; the latest phase 3 results are still company-reported.
YN001 is an experimental liposomal rosuvastatin that tries to deliver a statin straight into atherosclerotic plaque via the CD44 protein. The idea, the early data, the phase 2b PURIFY-TIMI 81 trial, and what it does not yet mean.
A faster resting pulse goes with higher risk in large cohorts. Trials that slowed the heart with a drug helped one group of heart-failure patients and not people with stable coronary disease. What that says about reading your own number.
Calorie restriction, omega-3 and small lifestyle studies have all been reported to slow or reverse an epigenetic clock. What the trials measured, in whom, how large the changes were, and why a lower reading is not yet a longer life.
On 26 August the FDA approved the first drug in the class of broad RAS(ON) inhibitors, for metastatic pancreatic cancer. Median overall survival rose from 6.7 to 13.2 months. We go through the figures from primary sources, name the toxicity alongside the effect, and include the criticism — including the criticism the investigators raised themselves.
There are many estimates of biological age and they disagree with each other. What to do about it, and what to watch instead.
Articles in this section are educational and are not medical advice, a diagnosis, or a prescription. Consult a qualified professional before acting on anything you read here.