Publication
Du R et al., BMC Cardiovasc Disord 2014 (serial carotid MRI, rosuvastatin)
PMID 25022285
Serial carotid MRI, rosuvastatin 5–20 mg/day.
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Research papers, anchored to PubMed (PMID) or DOI.
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PMID 25022285
Serial carotid MRI, rosuvastatin 5–20 mg/day.
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PMID 22085316
Rosuvastatin 40 mg vs atorvastatin 80 mg, serial IVUS, 104 weeks, n=1,039.
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PMID 16533939
Rosuvastatin 40 mg/day, serial coronary IVUS, 24 months, 349 evaluable patients.
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PMID 40769373
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PMID 40683616
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DOI 10.64898/2026.01.13.698514v1
Allosteric control improved potency/specificity; in-vivo PCSK9 silencing remains preclinical.
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PMID 36139044
Free 2HPβCD stimulated macrophage cholesterol efflux but did not induce regression of established lesions in the tested ApoE-KO model.
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DOI 10.1093/eurheartj/ehad655.3257
Wang et al., abstract.
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DOI 10.1161/CIRC.152.suppl_3.4365849
Ldlr-/- mice n=96; aortic-root plaque area −27.2%, aortic-tree plaque burden −25.8%, CD68 macrophage infiltration −61.5%.
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DOI 10.1056/NEJMoa2511002
Randomized placebo-controlled Phase 3: крупное устойчивое снижение LDL-C; primary endpoint — lipid surrogate, не cardiovascular events.
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DOI 10.1056/NEJMoa2601283
Phase 1 interim n=35, human PCSK9/LDL signal and ≥1-year follow-up subset.
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DOI 10.1056/NEJMc2609825
Sustained ANGPTL3/atherogenic-lipid reductions at 1 year.
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PMID 21948719
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DOI 10.1002/smll.202200967
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PMID 41211945
15 участников, safety-first dose escalation, ACTRN12623000809639.
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PMID 28304224
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PMID 27846344
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