Biological age: why a single number settles nothing
There are many estimates of biological age and they disagree with each other. What to do about it, and what to watch instead.
Biological age is an attempt to describe, in one number, how far a body has travelled along ageing. The idea is easy to follow: the calendar is the same for everyone, bodies are not. The trouble starts when that number is read as a verdict or as a prize.
Why the estimates disagree
Biological age is not measured — it is estimated, by a model. There are many models, built on different inputs: some on blood chemistry, some on physical measures, some on epigenetic marks. Each carries its own assumptions and its own training population, so two calculators can legitimately return different numbers from the same lab panel. That is not one of them being broken; they are answering slightly different questions.
What to do about it
Watch the direction, not the absolute value — and only inside a single model. "Three years younger" between two different methods means nothing. The same estimate, computed twice six months apart by the same method, does say something.
And remember the model computes from what you gave it. A missing marker does not make the result more honest; it makes it more confident than it deserves to be.
A longer explanation of how these estimates are built is in Biological age: what it is and how it is measured.
Articles in this section are educational and are not medical advice, a diagnosis, or a prescription. Consult a qualified professional before acting on anything you read here.
Read next
- ResearchMedicine and treatment
Rasonque (daraxonrasib): the FDA has approved the first broad RAS(ON) inhibitor — what it changes and what it does not
On 26 August the FDA approved the first drug in the class of broad RAS(ON) inhibitors, for metastatic pancreatic cancer. Median overall survival rose from 6.7 to 13.2 months. We go through the figures from primary sources, name the toxicity alongside the effect, and include the criticism — including the criticism the investigators raised themselves.
7 min read
ExplainerMedicine and treatmentFlat feet in children and adolescents: when to observe, when to treat, and what the evidence shows
In most children a flat foot is a shape, not a disease: the arch matures on its own in the first decade. What decides is whether the foot is flexible and whether it hurts. What the insole trials showed, how a rigid foot differs from a flexible one, when surgery is discussed at all, and what to ask the orthopaedic surgeon.
16 min read
ExplainerBiomarkersWhat limits VO2max — lungs, heart or muscles — and how accurate the estimates are
VO2max is often described as a measure of the lungs. In healthy people the ceiling is set mostly by how much oxygen the heart and blood can deliver; the lungs become the limit only in particular situations. What changes with age, and how accurate lab tests, formulas and watches are.
12 min read