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Four investigational drugs lower lipoprotein(a) sharply in phase 2 trials. In September 2026 the first trial that counted heart attacks and strokes missed its endpoint. What was measured, on whom, and what the result does not settle.
Anti-VEGF injections have preserved vision in large randomised trials of regular treatment. Newer drugs and an implant were shown to be no worse at longer intervals, each with its own safety profile; the latest phase 3 results are still company-reported.
A TSH below the range with normal T4 and T3 often returns to normal on repeat. When it persists, large cohorts link a TSH below 0.1 to atrial fibrillation and fractures, but the one randomised trial of treatment was small and inconclusive.
YN001 is an experimental liposomal rosuvastatin that tries to deliver a statin straight into atherosclerotic plaque via the CD44 protein. The idea, the early data, the phase 2b PURIFY-TIMI 81 trial, and what it does not yet mean.
Near focus fades with age for almost everyone. What reading glasses, multifocal contact lenses, the newer pupil-constricting drops and lens replacement have each been tested on, what the trials measured, and where the trade-offs are.
Skipped or extra beats are usually premature beats. What a basic workup includes, which findings change the picture — burden, heart structure, beats after exercise — and what trials of drugs, ablation and coffee actually measured.
For meniscus and ACL tears, randomised trials, including one against sham surgery, have compared surgery with rehabilitation. What they found, what a meniscal tear on MRI means after 50, and what the trials leave open.
Finding something early is not the same as changing what happens next. Which common screening tests for adults over forty have trial or USPSTF support, which are recommended against, and where the evidence stops.
In most children a flat foot is a shape, not a disease: the arch matures on its own in the first decade. What decides is whether the foot is flexible and whether it hurts. What the insole trials showed, how a rigid foot differs from a flexible one, when surgery is discussed at all, and what to ask the orthopaedic surgeon.
Parents of a child older than seven are told two opposite things: that it is too late, and that a new method changes everything. What the trials in this age group actually found — glasses alone, patching and atropine, binocular games, levodopa — which age ranges regulators authorised and on what data, and what these studies do not say.
On 26 August the FDA approved the first drug in the class of broad RAS(ON) inhibitors, for metastatic pancreatic cancer. Median overall survival rose from 6.7 to 13.2 months. We go through the figures from primary sources, name the toxicity alongside the effect, and include the criticism — including the criticism the investigators raised themselves.
Articles in this section are educational and are not medical advice, a diagnosis, or a prescription. Consult a qualified professional before acting on anything you read here.