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Biomarker explainers, longevity research and product updates — in one feed.

ExplainerBiomarkers
A stable plaque: what the word means in a report, and what is done about it
Carotid plaque is usually found by accident, and the report comes back with a percentage, a "smooth contour" and the word "stable". Here is what in that is measured and what is interpretation: why the percentage is not a severity score, what "stability" actually stands for, why calcification is not a synonym for danger, and which treatments have changed plaque in studies rather than in advertising.
September 10, 202619 min read
ExplainerBiomarkers
The omega-3 index: how to read your number and what actually raises it
You are holding a report with a percentage on it and no idea what to do with it. What is actually measured under the name "omega-3 index", why two laboratories do not compare, where the 4% and 8% zones came from, what genuinely moves the marker — and where the evidence stops.
September 9, 202618 min read
ExplainerBiomarkers
Left ventricular hypertrophy: is it reversible, and by what exactly
"Thickened left ventricular wall" in an echocardiography report causes no sensation and is almost always found while looking for something else. What sits behind the phrase, what measures it, what actually reduces myocardial mass in trials — and why "regression is accompanied by fewer events" and "regression reduces risk" are different claims.
September 8, 202614 min read
ExplainerStress
Cortisol and ageing: what is proven and what is not
"Does cortisol age you" is really three different questions, and the evidence behind them differs in strength. What is shown about age-related change in the rhythm, what is associated with outcomes and by what design, what the field does not have at all — and what gets sold in that gap.
September 7, 202617 min read
ExplainerMetabolism
Hepatic steatosis: what is proven in treatment and what is merely sold
Liver fat is usually an incidental finding, and what drives the prognosis is not the fat but the fibrosis stage. What changed in the name of the diagnosis, how stage is measured, what has actually been tested — and why the pharmacy shelf fails a single question about endpoints.
September 6, 202612 min read
ExplainerBiomarkers
VO2max and lifespan: how large the association is, and in whom
Fitness is among the strongest observational predictors of mortality. How large the association actually is, where the gradient is steepest, what randomised trials did not show, and why clinical-cohort numbers cannot be compared with a watch reading.
September 5, 202614 min read
ExplainerBiomarkers
LDL cholesterol: why it is the number that decides, and how low it is taken today
A lipid panel has several lines, but the decision is built around one. Where LDL's privileged position comes from, what levels it is lowered to, what lowers it — and where the evidence stops.
September 4, 20269 min read
ExplainerBiomarkers
Biological age vs chronological age: what the gap means
The difference between a biological age estimate and the calendar is not a subtraction but a regression residual. What is known about the gap, in whom it was shown, and what it does not say.
September 3, 20267 min read
ExplainerBiomarkers
How biological age is calculated: four methods and why their numbers disagree
Epigenetic clocks, composite scores from clinical labs, functional tests and consumer kits count different things — which is why they give different numbers for the same person. What each method measures, where the disagreement comes from, and what follows from it.
September 2, 20265 min read
ExplainerBiomarkers
Grip strength in clinical practice: what it predicts and what it does not
The dynamometer sits inside the sarcopenia definition, the frailty phenotype and preoperative assessment. What is actually measured there, why cut-offs do not transfer between devices and countries — and why the association between weak grip and worse outcomes does not make grip a target.
September 1, 202611 min read
ExplainerHow Lonevi works
Limits of the summary: what it can and cannot do
The Lonevi summary is not a diagnosis and not a replacement for a doctor. Where the line runs, and how to use it.
August 13, 20261 min read
ExplainerData and privacy
What happens to your data
Who can see your record, what survives account deletion, and why the link you give a doctor expires.
August 6, 20262 min read

Articles in this section are educational and are not medical advice, a diagnosis, or a prescription. Consult a qualified professional before acting on anything you read here.

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A stable plaque: what the word means in a report, and what is done about it

The omega-3 index: how to read your number and what actually raises it

Left ventricular hypertrophy: is it reversible, and by what exactly

Cortisol and ageing: what is proven and what is not

Hepatic steatosis: what is proven in treatment and what is merely sold

VO2max and lifespan: how large the association is, and in whom

LDL cholesterol: why it is the number that decides, and how low it is taken today

Biological age vs chronological age: what the gap means

How biological age is calculated: four methods and why their numbers disagree

Grip strength in clinical practice: what it predicts and what it does not

Limits of the summary: what it can and cannot do

What happens to your data